Let’s take a look at a survey that tests the suitability of quadriceps strength as a prognostic factor for mortality in COPD patients.
- Prognosis of COPD is difficult due to the complexity of contributing factors.
- Muscle weakness progresses due to and further contributes to exercise intolerance.
- Quadriceps strength was measured in COPD patients over several years.
- Transplantation-free survival is reduced in COPD patients with reduced quadriceps strength.
- Transplantation-free survival is not affected by COPD severity.
Reduced quadriceps strength is a predictor of increased mortality risk in COPD patients.
Quadriceps maximal voluntary contraction force (QMVC) was measured in patients in which quadriceps strength had been measured in the preceding five years. Primary endpoints studied were death or lung transplantation (as confirmed by primary care physician).
Transplantation-free survival (TFS) is significantly reduced in COPD patients with reduced quadriceps strength. TFS is not affected by the severity of COPD according to GOLD levels.
Quadriceps strength is a strong predictor of mortality. Reduced quadriceps strength/increased quadriceps muscle weakness is highly correlated with increased risk of mortality.